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AllSince 2019
:: Volume 31, Issue 2 (2-2021) ::
مجله‌ی بررسی‌ها 2021, 31(2): 441-459 Back to browse issues page
Statistical Study to Find the Optimal Dose of the First Phase in Leukemia Patients
Habib Jafari , Soleiman Khazaee , Anita Abdollahi Nanvapisheh *
Abstract:   (656 Views)
Abstract. In this paper, a structured framework for determining the optimal dose of the first phase in leukemia patients is presented. And here we describe and discuss the key parameters that are needed to set up and run a CRM trial. These are: number of doses; maximum tolerable dose; Target Toxicity Level Dose-toxicity model; Dose-toxicity skeleton; Sample size and cohort size and Stopping rules.

Keywords: Number of doses, target toxicity level, dose-toxicity model, dose-toxicity skeleton, sample size and cohort size and stopping rules.
Full-Text [PDF 939 kb]   (688 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2021/08/28 | Accepted: 2022/09/18 | Published: 2021/02/28
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Jafari H, Khazaee S, Abdollahi Nanvapisheh A. Statistical Study to Find the Optimal Dose of the First Phase in Leukemia Patients. مجله‌ی بررسی‌ها 2021; 31 (2) :441-459
URL: http://ijoss.srtc.ac.ir/article-1-411-en.html

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 31, Issue 2 (2-2021) Back to browse issues page
مجله‌ی بررسی‌های آمار رسمی ایران Ijoss Iranian Journal of Official Statistics Studies
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